Translating our discoveries into clinical care
All scientific research conducted at Ear Science Institute Australia aims to enhance the lives of people living with ear and hearing disorders.
We provide the foundation of knowledge for the Institute, our team includes scientific disciplines such as biochemistry, microbiology, physiology, and pharmacology, and involves laboratory studies with cell cultures, animal studies or physiological experiments.
Our basic science or Hearing Therapeutics team works in close collaboration with the Brain and Hearing Team and the clinicians in Lions Hearing clinic, extending their investigations into behavioural and social sciences as well, which have significant relevance for ear and hearing health.
Main areas of research include small molecules, DNA and viable cell targeting to middle and inner ear, using cutting-edge advanced bio-nanotechnology and pharmaceutical sciences. The research focuses on using bile acids as a bio-nano platform for therapeutic delivery that is well-aligned with global regulatory organisations.
Wound Healing, Tissue Repair & Fibrosis
Efficient wound healing is essential for the repair and restoration of tissue function following injury. Eardrum perforations, chronic middle ear disease and fibrosis (scarring) caused by physical trauma or infection are just some of the types of injury that can lead to hearing loss.
Our research investigates the cell and molecular responses that drive wound healing and repair in the ear. Using this knowledge, we are identifying new ways to effectively repair damage to the middle and inner ear.
Gene-based therapeutics research aims to explore two main lines of research enquiries. The first is the applications of genes in hair cell regeneration to treat hearing impairment. The second is utilising stem cells to generate patient-specific hair cells and recover hearing loss. The research includes the newly developed patient-specific induced pluripotent stem cell and inner ear organoid model that will allow the exploration of many aspects of inner ear cell biology and cell engineering in the search for a cure for hearing loss.
Scaffolds and implants
Scaffolds and implants-based research aims to develop commercial end-user devices that can aid damaged ear drums. With the support of a Wellcome Trust Grant, and developed in conjunction with Deakin University, ClearDrum® is a prosthetic device designed for those with chronic middle ear disease, leading to perforation. This ground-breaking device, which acts as a full or partial artificial ear drum, will increase the success rate of surgery for patients and optimise healing.
Discovery through to translation
With the support of a Wellcome Trust Grant and developed in conjunction with Deakin University, ClearDrum® is a prosthetic device designed for those with chronic middle ear disease, leading to perforation.
This ground-breaking device, which acts as a full or partial artificial eardrum, will increase the success rate of surgery for patients and optimise healing.