Basic Research Publications

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Publications 2017:

Allardyce B, Rajkhowa R, Redmond S, Atlas M, Dilley R, Wang X. Glycerol-plasticised silk membranes made from formic acid are ductile, transparent and degradation-resistant. Materials Science and Engineering C. 80, p. 165-173; 2017.

Boutilier JK, Taylor RL, Mann T, McNamara E, Hoffman GJ, Kenny J, Dilley RJ, Henry P, Morahan G, Laing NG, Nowak KJ. (2017). "Gene Expression Networks in the Murine Pulmonary Myocardium Provide Insight into the Pathobiology of Atrial Fibrillation." G3: Genes, Genomes, Genetics 7(9): 2999-3017.

Law N, Doney B, Glover H, Qin Y, Aman ZM, Sercombe TB, Liew LJ, Dilley RJ, Doyle BJ. Characterisation of Hyaluronic Acid Methylcellulose Hydrogels for 3D Bioprinting. Journal of the Mechanical Behavior of Biomedical Materials. Accepted for publication.

Liew LJ, Ong HT, Dilley RJ. Isolation and culture of adipose-derived stromal cells from sub-cutaneous fat. in “Fibrosis - Methods and Protocols: Springer series Methods in Molecular Biology (Ed. L Rittie). In press.

Liew LJ, Day RM, Dilley RJ. A novel 3D tympanic membrane organ culture method using cell culture well inserts. Tissue Engineering Part C. Accepted for publication January 2017.

Ong HT, Redmond S, Marano R, Atlas MD, von Unge M, Aabel P, Dilley RJ. Paracrine activity from adipose-derived stem cells on in vitro wound healing in human tympanic membrane keratinocytes. Stem Cells and Development. 26(6):405-418; 2017. doi: 10.1089/scd.2016.0204. Epub 2016 Nov 21.

Wang A, Liew LJ, Shen Y, Wang JT, von Unge M, Atlas MD, Dilley RJ. In response to the letter to the editor regarding: Rat model of chronic tympanic membrane perforation: Ventilation tube with mitomycin C and dexamethasone. International Journal of Pediatric Otorhinolaryngology. 93: 88-96; 2017.

Wang A, Liew LJ, Shen Y, Wang JT, von Unge M, Atlas MD, Dilley RJ. In response to the letter to the editor regarding: Rat model of chronic tympanic membrane perforation: Ventilation tube with mitomycin C and dexamethasone. International Journal of Pediatric Otorhinolaryngology. 100: 256; 2017.

Publications 2016:

Allardyce BJ, Rajkhowa R, Dilley RJ, Xie Z, Campbell L, Keating A, Atlas MD, von Unge M, Wang X. Comparative acoustic performance and mechanical properties of silk membranes for the repair of chronic tympanic membrane perforations. Journal of the Mechanical Behavior of Biomedical Materials. 64:65-74; 2016. doi: 10.1016/j.jmbbm.2016.07.017

Asgari A, Rafaut N, Morrison W, Dilley R, Knudsen R, Jones L, Sinclair R. A simple hair transplantation model to investigate follicular stem and progenitor cells and their interaction with surrounding skin. Wound Repair and Regeneration. 24(4):679-85; 2016. doi: 10.1111/wrr.12435

Liew LJ, Ong HT, Dilley RJ. Isolation and culture of adipose-derived stromal cells from sub-cutaneous fat. in “Fibrosis - Methods and Protocols: Springer series Methods in Molecular Biology (Ed. L Rittie). In press.

Shen Y, Teh BM, Dilley RJ. Response to “Tympanic Membrane Repair Using Silk. The Laryngoscope. Published online: 1 March 2016. doi: 10.1002/lary.25935

Wang A, Shen Y, Liew LJ, Wang JT, von Unge M, Atlas MD, Dilley RJ. Rat model of chronic tympanic membrane perforation: Ventilation tube with mitomycin C and dexamethasone. International Journal of Pediatric Otorhinolaryngology. 80(1):61-68; 2015. doi: 10.1016/j.ijporl.2015.11.010

Publications 2015:

Allardyce BJ, Rajkhowa R, Dilley RJ, Atlas MD, Kaur J, Wang X. The impact of degumming conditions on the properties of silk films for biomedical applications. Textile Research Journal, 0040517515586166; 2015.

Bosman A, Edel M, Blue G, Dilley RJ, Harvey RP, Winlaw D. Bioengineering and stem cell technology in the treatment of congenital heart disease. Journal of Clinical Medicine. 4(4):768-781; 2015.

Danti S, Mota C, D’Alessandro D, Trombi L, Ricci C, Redmond SL, De Vito A, Pini R, Dilley RJ, Moroni L, Berrettini S. Tissue engineering of the tympanic membrane using electrospun PEOT/PBT copolymer scaffolds: a morphologic in vitro study. Hearing, Balance and Communication. 13(4):133-147; 2015. doi: 10.3109/21695717.2015.1092372

Lui LL, Mokri Y, Reser DH, Rosa MGP, Rajan R. Responses of neurons in the marmoset primary auditory cortex to interaural level differences: comparison of puretones and vocalizations. Frontiers in Neuroscience, 9:Article 132; 2015. doi: 10.3389/fnins.2015.00132

Marano RJ, Wallace HJ, Wijeratne D, Fear MW, Wong HS, O’Handley R. Secreted biofilm factors adversely affect cellular wound healing responses in vitro. Scientific Reports. 17(5):13296. doi: 10.1038/srep13296.

Palomo ABA, McLenachan S, Chen FK, Da Cruz L, Dilley RJ, Requena J, Lucas M, Lucas A, Drukker M, Edel MJ. Prospects for clinical use of reprogrammed cells for autologous treatment of macular degeneration. Fibrogenesis & Tissue Repair.  8(1):9; 2015. doi: 10.1186/s13069-015-0026-9.

Visweswaran M,  Pohl S,  Arfuso F, Newsholme P, Dilley RJ, Perzaiz S, Dharmarajan A.  Multi-lineage differentiation of mesenchymal stem cells - Wnt or not to Wnt. The International Journal of Biochemistry & Cell Biology. 68:139-47; 2015. doi: 10.1016/j.biocel.2015.09.008.

Visweswaran M,  Schiefer L, Arfuso F, Dilley RJ, Newsholme P, Dharmarajan A. Wnt antagonist secreted frizzled-related protein 4 up-regulates adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells. Plos One. 10 (2): e0118005; 2015. doi: 10.1371/journal.pone.0118005.

Wang AY, Shen Y, Liew LJ, Wang JT, von Unge M, Atlas MD, Dilley RJ. Searching for a rat model of chronic tympanic membrane perforation: Healing delayed by mitomycin C/dexamethasone but not paper implantation or iterative myringotomy. International Journal of Pediatric Otorhinolaryngology. 79(8):1240-7; 2015. doi: 10.1016/j.ijporl.2015.05.020.

Publications 2014:

Allardyce BJ, Rajkhowa R, Atlas MD, Dilley RJ, Wang X.  Silk films as a robust support to repair large perforations of the tympanic membrane. Proceedings of The 89th Textile Institute World Conference, 2-6 Nov 2014, Wuhan, China.

Hsiao ST, Dilley RJ, Dusting GJ, Lim SY. Ischemic preconditioning for cell-based therapy and tissue engineering. Pharmacol Ther. 140(2):141–153; 2014. doi: 10.1016/j.pharmthera.2013.12.002.           

Lim SY, Sivakumaran P, Crombie DE, Dusting GJ, Pébay A, Dilley RJ. Enhancing Human Cardiomyocyte Differentiation from Induced Pluripotent Stem Cells with Trichostatin-A. in “iPS Cells: Generation Characterization and Differentiation - Methods and Protocols” Springer series Methods in Molecular Biology. 1357:415-21; 2016. doi: 10.1007/7651_2014_160.

Marano RJ and Ben-Jonathon N. Minireview: Extrapituitary Prolactin: An Update on the Distribution, Regulation, and Functions. Molecular Endocinology. 28(5):622-33; 2014. doi:10.1210/me.2013-1349

Palomo ABA, Lucas M, McLenachan S, Requena J, Farrera Sal M, Dilley RJ, Lucas A, Chen F, Alvarez I, Jaraquemada D, Edel MJ. The power and the promise of cell reprogramming: Personalized autologous body organ and cell transplantation. Journal of Clinical Medicine, 3(2):373-387; 2014. doi:10.3390/jcm3020373

Wang AY, Shen Y, Wang JT, Eikelboom RH, Dilley RJ. Animal models of chronic tympanic membrane perforation. In response to: Plasminogen initiates and potentiates the healing of acute and chronic tympanic membrane perforations in mice. Clinical and Translational Medicine. 3:1-5; 2014. doi: 10.1186/2001-1326-3-5. PubMed PMID: 24669846; PubMed Central PMCID: PMC3987050.

Wang AY, Shen Y, Wang JT, Friedland PL, Atlas MD, Dilley R. Animal Models of Chronic Tympanic Membrane Perforation: a ‘Time-Out’ to Review Evidence and Standardize Design. International Journal of Pediatric Otorhinolaryngology. 78(12):2048-2055; 2014; 10.1016/j.ijporl.2014.10.007

Publications 2013: 

Hsiao ST, Lokmic Z, Peshavariya H, Abberton KM, Dusting GJ, Lim SY, Dilley RJ. Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose-derived stem cells. Stem Cells Dev. 22(10):1614-23; 2013.

Lim SY, Sivakumaran P, Crombie DE, Dusting GJ, Pébay A, Dilley RJ. Trichostatin a enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering. Stem Cells Transl Med. 2(9):715-25; 2013.

Marano R, Tickner J, Redmond S. Age related changes of gene expression with the cochlear of C57BL/6J mice. Ageing Clinical and Experimental Research. 24(9):603-611; 2013. doi:10.3275/8590.

Marano RJ, Tickner J and Redmond SL. Prolactin expression in the cochlea of aged BALB/C mice is gender bias and correlates to loss of bone mineral density and hearing loss. Plos ONE. 8(5):1-7; 2013.

Matsuda K, Falkenberg KJ, Woods AA, Choi YS, Morrison WA, Dilley RJ. Adipose-derived stem cells promote angiogenesis and tissue formation for in vivo tissue engineering. Tissue Eng Part A. 19(11-12):1327-35; 2013.

Santa Maria PL. In response to: “Regeneration of Chronic Tympanic Membrane Perforation Using an EGF-Releasing Chitosan Patch”. Letter to the editor. Tissue Engineering Part A. 19(19-20); 2013.

Shen Y, Redmond S, Teh B, Yan S, Wang Y, Zhou L, Budgeon C, Eikelboom RH, Atlas MD, Dilley RJ, Zheng MH, Marano RJ. Scaffolds for tympanic membrane regeneration in rats. Tissue Engineering Part A. 19:657-668; 2013. doi: 10.1089/ten.tea.2012.0053

Shen Y, Redmond SL, Teh BM, Yan S, Wang Y, Atlas MD, Dilley RJ, Zheng M-H, Marano RJ. Tympanic membrane repair using silk fibroin and acellular collagen scaffolds. Laryngoscope. 123(8):1976-82; 2013. doi: 10.1002/lary.23940.

Teh BM, Marano RJ, Shen Y, Friedland PL, Dilley RJ, Atlas MD. Tissue Engineering of the Tympanic Membrane. Tissue Engineering Part B. 19(2):1-17; 2013. doi:10.1089/ten.teb.2012.0389

Teh B, Redmond S, Shen Y, Atlas MD, Marano R, Dilley R. TGF-α/HA complex promotes tympanic membrane keratinocyte migration and proliferation via ErbB1 receptor. Experimental Cell Research. 319(6):790-199; 2013.

Publications 2012:

Hsiao ST, Asgari A, Lokmic Z, Sinclair R, Dusting GJ, Lim SY, Dilley RJ. Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue. Stem Cells Dev. 21(12):2189-203, 2012.

Levin B, Redmond SL, Rajkhowa R, Eikelboom RH, Marano RJ, Atlas MD. Utilising silk fibroin membranes as scaffolds for the growth of tympanic membrane keratinocytes and their application to myringoplasty surgery. Journal of Laryngology and Otology. 127(Suppl 1): S13-20; 2012. http://dx.doi.org/10.1017/S002221511200166.

Lim M, Friedland P, Thompson A, Boedinghaus R, Atlas MD. Otitic Meningitis, Superior Semicircular Canal Dehiscence and Encephalocele: a case series. Otology & Neurotology. 33(4):610-2; 2012.

Lim SY, Hsiao ST, Lokmic Z, Sivakumaran P, Dusting GJ, Dilley RJ. Ischemic preconditioning promotes intrinsic vascularization and enhances survival of implanted cells in an in vivo tissue engineering model. Tissue Eng Part A. 18:2210-9, 2012.

Lim SY, Lee DG, Sivakumaran P, Crombie D, Slavin J, Dottori M, Conley B, Denham M, Leung J, Tee R, Dusting GJ, Pebay A, Dilley RJ. In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation. Biochem Biophys Res Commun. 25;422(1):75-9, 2012.

Nguyen PD, Hsiao ST, Sivakumaran P, Lim SY, Dilley RJ. Enrichment of neonatal rat cardiomyocytes in primary culture facilitates long-term maintenance of contractility in vitro. Am J Physiol Cell Physiol. 303(12):C1220-8, 2012.

Tee R, Morrison WA, Dusting GJ, Liu GS, Choi YS, Hsiao ST, Dilley RJ. Transplantation of engineered cardiac muscle flaps in syngeneic rats. Tissue Eng Part A. 18(19-20):1992-9; 2012.

Teh B, Hall C, Chan S. Pneumosinus dilatans, pneumocoele or air cyst? A case report and literature review. Journal of Laryngology and Otology. 126:88-93; 2012.

Teh B, Shen Y, Friedland P, Atlas M, Marano R. A review on the use of hyaluronic acid in tympanic membrane wound healing. Expert Opinion on Biological Therapy. 12(1):23-36; 2012.

Publications 2011:

Marano RJ, Redmond SL. In vitro cultured primary cells from a human utricle explant possesses hair cell like characteristics. Journal of Molecular Histology of Neurology. 42(4):365-70; 2011.

Rajkhowa R, Levin B, Redmond SL, Li LH, Wang L, Kanwar JR, Atlas MD, Wang X. Structure and properties of biomedical films prepared from aqueous and acidic silk fibroin solutions. Journal of Biomedical Materials Research Part A. 97A:37-45; 2011.

Redmond SL, Levin B, Heel KA, Atlas MD, Marano R. Phenotypic and genotypic profile of human tympanic membrane derived cultured cells. J Molecular Histology. 42(1):15-25; 2011. Winner Valerie Alder Research Prize for the best hearing-related scientific paper in 2011.

Santa Maria PL, Redmond SL, McInnes RL, Atlas MD, Ghassemifar R. Tympanic membrane wound healing in rats as assessed by transcriptome profiling. Laryngoscope. 121(5):1040-8; 2011.

Santa Maria PL, Redmond SL, Atlas MD, Ghassemifar R. Keratinocyte growth factor 1, fibroblast growth factor 2 and 10 in the healing tympanic membrane following perforation in rats assessed by transcriptome profiling and immunohistochemistry. Journal of Molecular Histology. 42(1):47-58; 2011.

Shen Yi, Teh BM, Friedland PL, Eikelboom RH, Atlas MD. To pack or not to pack? Laryngoscope. 121(5):1040-8; 2011.

Teh B, Nickless D, Seevanayagam S. Malignant ossifying fibromyxoid tumour: a large anterior mediastinal mass. Pathology. 43(7):749; 2011.

Teh B, Hall C, Kleid S. Infected tracheocoele (acquired tracheal diverticulum): case report and literature review. The Journal of Laryngology & Otology. 125(05):540-5; 2011.

Publications 2010:

Levin B, Fisher P, Kuthubutheen J. Penetrating Facial Injury – A fortunate functional and cosmetic outcome. Otolaryngology - Head and Neck Surgery. 142(3):S36-S38; 2010.     

Levin B, Redmond SL, Rajkhowa R, Marano RJ, Atlas MD. Preliminary results of the application of a silk fibroin scaffold to otology. Otolaryngology Head and Neck Surgery. 142:S33-35; 2010.

Santa Maria PL, Redmond SL, Atlas MD and Ghassemifar R. Histology of the healing tympanic membrane following perforation in rats. The Laryngoscope. 120:2061-2070; 2010.

Santa Maria PL, Redmond SL, Atlas MD and Ghassemifar R. The role of epidermal growth factor in the healing tympanic membrane following perforation in rats. Journal of Molecular Histology. 42(6):309-314; 2010.

Publications 2009:

Levin B, Rajkhowa R, Redmond S, Atlas M. Grafts in Myringoplasty:  Utilising a Silk Fibroin Scaffold as a Novel Device (Review Article). Expert Rev Med Devices. 6(6):653-64; 2009.

Publications 2007:

Santa Maria PL, Atlas MD, Ghassemifar R. Chronic tympanic membrane perforation: a better animal model is needed. Wound Repair Regen. 2007 Jul-Aug;15(4):450-8.

Publications 2006:

Anandacoomaraswamy KS, Dutton N, Rajan GP, Eikelboom RH, Atlas MD, Robertson T (2005) Utilisation of fresh human tympanic membranes for structural analysis and cytokeratins immunocytochemistry implementing resin techniques, ACTA Oto-laryngologica, 126(2):149-53.

Publications 2016: